rank epistasis

a rank-based method of measuring genome connectivity

This project introduces rank epistasis as a rank-based analysis of genome connectivity. Rank epistasis is unique in that it makes no assumption about baseline fitness interactions and requires only comparative fitness levels, not absolute.

Preliminary results were published and presented at the 2020 Artificial Life Conference.

In short, the metric exists in four steps:

  1. Rank all organisms in population based on performance
  2. Mutate all organisms at a particular locus
  3. Rank all these mutatnts using the same methods from step 1
  4. Compute the edit distance between the two rankings.

Find the github repo for the project here.